| Post Translational Modifications | The protein is first synthesized as a holoprotein form of 98 kDa and rapidly processed into the gamma-secretase-activating protein 16 kDa C-terminal form, which constitutes the predominant form. |
| Function | Regulator of gamma-secretase activity, which specifically activates the production of amyloid-beta protein (amyloid-beta protein 40 and amyloid-beta protein 42), without affecting the cleavage of other gamma-secretase targets such has Notch. The gamma-secretase complex is an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Specifically promotes the gamma-cleavage of APP CTF-alpha (also named APP-CTF) by the gamma-secretase complex to generate amyloid-beta, while it reduces the epsilon-cleavage of APP CTF-alpha, leading to a low production of AICD. |
| Protein Name | Gamma-Secretase-Activating ProteinGsapProtein Pigeon Homolog Cleaved Into - Gamma-Secretase-Activating Protein 16 Kda C-Terminal FormGsap-16k |
| Cellular Localisation | Golgi ApparatusTrans-Golgi Network |
| Alternative Protein Names | Gamma-Secretase-Activating Protein proteinGsap proteinProtein Pigeon Homolog Cleaved Into - Gamma-Secretase-Activating Protein 16 Kda C-Terminal Form proteinGsap-16k proteinGSAP proteinPION protein |
Information sourced from Uniprot.org
