Human FPR1 protein (Recombinant) (N-GST) (STJP004311)

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STJP004311
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human FPR1-N-GST protein was developed from e. coli and has a target region of N-GST. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: FPR1
Gene ID: 2357
Uniprot ID: FPR1_HUMAN
Immunogen Region: Arg163-Val242
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylated.which is necessary for desensitization.
Function High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors. Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Receptor for TAFA4, mediates its effects on chemoattracting macrophages, promoting phagocytosis and increasing ROS release. Receptor for cathepsin CTSG, leading to increased phagocyte chemotaxis.
Protein Name Fmet-Leu-Phe Receptor
Fmlp Receptor
N-Formyl Peptide Receptor
Fpr
N-Formylpeptide Chemoattractant Receptor
Database Links Reactome: R-HSA-418594
Reactome: R-HSA-444473
Reactome: R-HSA-6783783
Reactome: R-HSA-6798695
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Internalizes In Presence Of Its Ligands
Fmlp
Tafa4 And Ctsg
Alternative Protein Names Fmet-Leu-Phe Receptor protein
Fmlp Receptor protein
N-Formyl Peptide Receptor protein
Fpr protein
N-Formylpeptide Chemoattractant Receptor protein
FPR1 protein

Information sourced from Uniprot.org

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