| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.1 EU/Mu g of the protein by LAL method. |
| Immunoreactivity: | Measured by its binding ability in a functional ELISA. Immobilized Human EphA7 at 0.5 Mu g/mL (100 Mu L/well) can bind Human EFNA4 with a linear range of 0.039-0.942 ng/mL. |
| Gene Symbol: | EFNA4 |
| Gene ID: | 1945 |
| Uniprot ID: | EFNA4_HUMAN |
| Immunogen Region: | Leu26-Gly171 |
| Immunogen: | Recombinant Human Ephrin-A4/EFNA4 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Leu26-Gly171) of human Ephrin-A4/EFNA4 (Accession # NP_005218.1) fused with an Fc, 6×His tag at the C-terminus. |
| Immunogen Sequence: | LRHVVYWNSSNPRLLRGDAV VELGLNDYLDIVCPHYEGPG PPEGPETFALYMVDWPGYES CQAEGPRAYKRWVCSLPFGH VQFSEKIQRFTPFSLGFEFL PGETYYYISVPTPESSGQCL RLQVSVCCKERKSESAHPVG SPGESG |
| Function | Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. May play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils. |
| Protein Name | Ephrin-A4Eph-Related Receptor Tyrosine Kinase Ligand 4Lerk-4 |
| Database Links | Reactome: R-HSA-2682334Reactome: R-HSA-3928663Reactome: R-HSA-3928665 |
| Cellular Localisation | Isoform 1: Cell MembraneLipid-AnchorGpi-AnchorIsoform 2: Secreted |
| Alternative Protein Names | Ephrin-A4 proteinEph-Related Receptor Tyrosine Kinase Ligand 4 proteinLerk-4 proteinEFNA4 proteinEPLG4 proteinLERK4 protein |
Information sourced from Uniprot.org