Human EFNB1 protein (Recombinant-Active) (C-hFc-His) (STJP012055)

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STJP012055-100
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Host: Mammalian Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Active-Human EFNB1-C-hFc-His protein was developed from mammalian cells and has a target region of C-hFc-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Dilution Range: Reconstitute in sterile water for a stock solution.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: <0.1 EU/Mu g of the protein by the LAL method.
Gene Symbol: EFNB1
Gene ID: 1947
Uniprot ID: EFNB1_HUMAN
Immunogen Region: Leu28-Gly232
Immunogen: Homo sapiens (Human)
Post Translational Modifications Inducible phosphorylation of tyrosine residues in the cytoplasmic domain. Proteolytically processed. The ectodomain is cleaved, probably by a metalloprotease, to produce a membrane-tethered C-terminal fragment. This fragment is then further processed by the gamma-secretase complex to yield a soluble intracellular domain peptide which can translocate to the nucleus. The intracellular domain peptide is highly labile suggesting that it is targeted for degradation by the proteasome.
Function Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binding to Eph receptors residing on adjacent cells leads to contact-dependent bidirectional signaling into neighboring cells. Shows high affinity for the receptor tyrosine kinase EPHB1/ELK. Can also bind EPHB2 and EPHB3. Binds to, and induces collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons.
Protein Name Ephrin-B1
Efl-3
Elk Ligand
Elk-L
Eph-Related Receptor Tyrosine Kinase Ligand 2
Lerk-2 Cleaved Into - Ephrin-B1 C-Terminal Fragment
Ephrin-B1 Ctf - Ephrin-B1 Intracellular Domain
Ephrin-B1 Icd
Database Links Reactome: R-HSA-2682334
Reactome: R-HSA-3928662
Reactome: R-HSA-3928664
Reactome: R-HSA-3928665
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Membrane Raft
May Recruit Grip1 And Grip2 To Membrane Raft Domains
Ephrin-B1 C-Terminal Fragment: Cell Membrane
Ephrin-B1 Intracellular Domain: Nucleus
Colocalizes With Zhx2 In The Nucleus
Alternative Protein Names Ephrin-B1 protein
Efl-3 protein
Elk Ligand protein
Elk-L protein
Eph-Related Receptor Tyrosine Kinase Ligand 2 protein
Lerk-2 Cleaved Into - Ephrin-B1 C-Terminal Fragment protein
Ephrin-B1 Ctf - Ephrin-B1 Intracellular Domain protein
Ephrin-B1 Icd protein
EFNB1 protein
EFL3 protein
EPLG2 protein
LERK2 protein

Information sourced from Uniprot.org

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