Function | Co-chaperone for HSPA8/Hsc70. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as a co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV. |
Protein Name | Dnaj Homolog Subfamily A Member 1Dnaj Protein Homolog 2HsdjHeat Shock 40 Kda Protein 4Heat Shock Protein J2Hsj-2Human Dnaj Protein 2Hdj-2 |
Database Links | Reactome: R-HSA-3371497 |
Cellular Localisation | MembraneLipid-AnchorCytoplasmMicrosomeNucleusPerinuclear RegionMitochondrionPrimarily Associated With MicrosomesA Minor Proportion Is Associated With MitochondriaPrimarily CytoplasmicA Minor Proportion Is Associated With Nuclei |
Alternative Protein Names | Dnaj Homolog Subfamily A Member 1 proteinDnaj Protein Homolog 2 proteinHsdj proteinHeat Shock 40 Kda Protein 4 proteinHeat Shock Protein J2 proteinHsj-2 proteinHuman Dnaj Protein 2 proteinHdj-2 proteinDNAJA1 proteinDNAJ2 proteinHDJ2 proteinHSJ2 proteinHSPF4 protein |
Information sourced from Uniprot.org