| Post Translational Modifications | The three-dimensional structure formed by the three intramolecular disulfide bridges is indispensable for effective bacterial killing. |
| Function | Host-defense peptide that has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Exhibits antimicrobial activity against Gram-negative E.coli and E.aerogenes and Gram-positive S.faecalis, S.aureus and B.cereus and the yeast C.albicans (in vitro). Interacts with pathogenic surface proteins and toxins, such as HIV-1 surface protein gp120 and B.anthracis anthrax lethal factor lef. Protects blood cells against infection with HIV-1 (in vitro). Inhibits enzymatic activity of B.anthracis lef/anthrax lethal factor (in vitro). Inhibits corticotropin (ACTH)-stimulated corticosterone production (in vitro). |
| Protein Name | Defensin Alpha 4Corticostatin Hp-4Hnp-4Hp-4Neutrophil Defensin 4 |
| Database Links | Reactome: R-HSA-1461973Reactome: R-HSA-1462054Reactome: R-HSA-6798695 |
| Cellular Localisation | SecretedCytoplasmic VesicleSecretory VesicleStored As Mature Peptide In Neutrophil Granules |
| Alternative Protein Names | Defensin Alpha 4 proteinCorticostatin Hp-4 proteinHnp-4 proteinHp-4 proteinNeutrophil Defensin 4 proteinDEFA4 proteinDEF4 protein |
Information sourced from Uniprot.org
