Human CYTH2 protein (Recombinant) (N-His) (STJP005876)

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STJP005876
€410.63 - €1,796.88
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CYTH2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: CYTH2
Gene ID: 9266
Uniprot ID: CYH2_HUMAN
Immunogen Region: Met1-Arg390
Immunogen: Homo sapiens (Human)
Function Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Activates ARF factors through replacement of GDP with GTP. The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane. Involved in neurite growth.
Protein Name Cytohesin-2
Arf Exchange Factor
Arf Nucleotide-Binding Site Opener
Protein Arno
Ph - Sec7 And Coiled-Coil Domain-Containing Protein 2
Database Links Reactome: R-HSA-6811438
Cellular Localisation Cell Membrane
Peripheral Membrane Protein
Cytoplasm
Cell Projection
Growth Cone
Cell Junction
Tight Junction
Adherens Junction
Both Isoform 1 And Isoform 2 Are Recruited To The Cell Membrane Through Its Association With Arl4a
Arl4c And Arl4d
They Require Also Interaction With Phosphoinositides For Targeting To Plasma Membrane
In Differentiating Neuroblastoma Cells
Colocalizes With Ccdc120 In Both Neurite Shaft And Growth Cone Areas
Alternative Protein Names Cytohesin-2 protein
Arf Exchange Factor protein
Arf Nucleotide-Binding Site Opener protein
Protein Arno protein
Ph - Sec7 And Coiled-Coil Domain-Containing Protein 2 protein
CYTH2 protein
ARNO protein
PSCD2 protein
PSCD2L protein

Information sourced from Uniprot.org