| Host: | HEK293 |
| Note: | STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human/Cynomolgus/Rhesus macaque ROR1-C-His-Avi protein was developed from hek293 and has a target region of C-His-Avi. For use in research applications. |
| Conjugation: | Biotin |
| Formulation: | Lyophilised from 0.2 µm filtered PBS solution pH7.4. |
| Dilution Range: | Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM |
| Storage Instruction: | The lyophilized protein is stable for at least 1 year from date of receipt at-20°C. |
| Endotoxin: | Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). |
| Gene Symbol: | ROR1 |
| Gene ID: | 4919 |
| Uniprot ID: | ROR1_HUMAN |
| Immunogen Region: | Gln30-Glu403 |
| Immunogen: | DNA sequence encoding Human/Cynomolgus/Rhesus macaque ROR1 including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology. |
| Function | Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling. In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells. Via IGFBP5 ligand, forms a complex with ERBB2 to enhance CREB oncogenic signaling. |
| Protein Name | Inactive Tyrosine-Protein Kinase Transmembrane Receptor Ror1Neurotrophic Tyrosine Kinase - Receptor-Related 1 |
| Database Links | Reactome: R-HSA-5140745 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinCell ProjectionAxon |
| Alternative Protein Names | Inactive Tyrosine-Protein Kinase Transmembrane Receptor Ror1 proteinNeurotrophic Tyrosine Kinase - Receptor-Related 1 proteinROR1 proteinNTRKR1 protein |
Information sourced from Uniprot.org