| Tissue Specificity | Widely expressed on all hematopoietic cells. |
| Function | Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including CD244/2B4 or CD2 to regulate immune cell function and activation. Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex. In turn, promotes LCK phosphorylation and subsequent activation. Induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244 initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T-lymphocytes and NK-cells. |
| Protein Name | Cd48 AntigenB-Lymphocyte Activation Marker Blast-1Bcm1 Surface AntigenLeukocyte Antigen Mem-102Slam Family Member 2Slamf2Signaling Lymphocytic Activation Molecule 2Tct.1Cd Antigen Cd48 |
| Database Links | Reactome: R-HSA-202733 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorMembrane RaftSecreted |
| Alternative Protein Names | Cd48 Antigen proteinB-Lymphocyte Activation Marker Blast-1 proteinBcm1 Surface Antigen proteinLeukocyte Antigen Mem-102 proteinSlam Family Member 2 proteinSlamf2 proteinSignaling Lymphocytic Activation Molecule 2 proteinTct.1 proteinCd Antigen Cd48 proteinCD48 proteinBCM1 proteinBLAST1 protein |
Information sourced from Uniprot.org
