Human CD328/SIGLEC7 protein (Recombinant) (N-His) (STJP006240)

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STJP006240
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CD328/SIGLEC7-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: SIGLEC7
Gene ID: 27036
Uniprot ID: SIGL7_HUMAN
Immunogen Region: Gly18-Leu353
Immunogen: Homo sapiens (Human)
Post Translational Modifications Tyrosine phosphorylated.
Function Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).
Protein Name Sialic Acid-Binding Ig-Like Lectin 7
Siglec-7
Adhesion Inhibitory Receptor Molecule 1
Airm-1
Cdw328
D-Siglec
Qa79 Membrane Protein
P75
Cd Antigen Cd328
Database Links Reactome: R-HSA-198933
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Sialic Acid-Binding Ig-Like Lectin 7 protein
Siglec-7 protein
Adhesion Inhibitory Receptor Molecule 1 protein
Airm-1 protein
Cdw328 protein
D-Siglec protein
Qa79 Membrane Protein protein
P75 protein
Cd Antigen Cd328 protein
SIGLEC7 protein
AIRM1 protein

Information sourced from Uniprot.org

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