Tissue Specificity | Detected in ovary, pancreas, intestine, colon, kidney, brain, thymus, lung, heart, liver, spleen, leukocyte, prostate and testis. |
Post Translational Modifications | |
Function | Catalyzes the NADPH-dependent reduction of carbonyl compounds to their corresponding alcohols. Has low NADPH-dependent oxidoreductase activity. Acts on several orthoquinones, acts as well on non-quinone compounds, such as isatin or on the anticancer drug oracin. Best substrates for CBR3 is 1,2- naphthoquinone, hence could play a role in protection against cytotoxicity of exogenous quinones. Exerts activity toward ortho-quinones but not paraquinones. No endogenous substrate for CBR3 except isatin has been identified. |
Protein Name | Carbonyl Reductase Nadph 3Nadph-Dependent Carbonyl Reductase 3Quinone Reductase Cbr3Short Chain Dehydrogenase/Reductase Family 21c Member 2 |
Database Links | Reactome: R-HSA-211945 |
Cellular Localisation | Cytoplasm |
Alternative ELISA Names | Carbonyl Reductase Nadph 3 ELISA kitNadph-Dependent Carbonyl Reductase 3 ELISA kitQuinone Reductase Cbr3 ELISA kitShort Chain Dehydrogenase/Reductase Family 21c Member 2 ELISA kitCBR3 ELISA kitSDR21C2 ELISA kit |
output | |
Information sourced from Uniprot.org