| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human CBL-N-GST protein was developed from e. coli and has a target region of N-GST. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | CBL |
| Gene ID: | 867 |
| Uniprot ID: | CBL_HUMAN |
| Immunogen Region: | Ser558-Gly816 |
| Immunogen: | Homo sapiens (Human) |
| Function | E3 ubiquitin-protein ligase that acts as a negative regulator of many signaling pathways by mediating ubiquitination of cell surface receptors. Accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, CSF1R, EPHA8 and KDR and mediates their ubiquitination to terminate signaling. Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation. Ubiquitinates EGFR and SPRY2. Ubiquitinates NECTIN1 following association between NECTIN1 and herpes simplex virus 1/HHV-1 envelope glycoprotein D, leading to NECTIN1 removal from cell surface. Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBLB, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA. |
| Protein Name | E3 Ubiquitin-Protein Ligase CblCasitas B-Lineage Lymphoma Proto-OncogeneProto-Oncogene C-CblRing Finger Protein 55Ring-Type E3 Ubiquitin Transferase CblSignal Transduction Protein Cbl |
| Database Links | Reactome: R-HSA-1059683Reactome: R-HSA-1236382Reactome: R-HSA-1295596Reactome: R-HSA-1433559Reactome: R-HSA-182971Reactome: R-HSA-2173789Reactome: R-HSA-5637810Reactome: R-HSA-5654726Reactome: R-HSA-5654727Reactome: R-HSA-5654732Reactome: R-HSA-5654733Reactome: R-HSA-6807004Reactome: R-HSA-8849469Reactome: R-HSA-8856825Reactome: R-HSA-8856828Reactome: R-HSA-8875360Reactome: R-HSA-912631Reactome: R-HSA-9680350Reactome: R-HSA-9706369Reactome: R-HSA-9706377 |
| Cellular Localisation | CytoplasmCell MembraneCell ProjectionCiliumGolgi ApparatusColocalizes With Fgfr2 In Lipid Rafts At The Cell Membrane |
| Alternative Protein Names | E3 Ubiquitin-Protein Ligase Cbl proteinCasitas B-Lineage Lymphoma Proto-Oncogene proteinProto-Oncogene C-Cbl proteinRing Finger Protein 55 proteinRing-Type E3 Ubiquitin Transferase Cbl proteinSignal Transduction Protein Cbl proteinCBL proteinCBL2 proteinRNF55 protein |
Information sourced from Uniprot.org