Human BCAS3 protein (Recombinant) (N-His) (STJP006000)

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STJP006000
£328.50 - £1,437.50
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human BCAS3-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: BCAS3
Gene ID: 54828
Uniprot ID: BCAS3_HUMAN
Immunogen Region: Met230-Gly546
Immunogen: Homo sapiens (Human)
Function Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation. Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin. Plays a regulatory role in autophagic activity. In complex with PHAF1, associates with the preautophagosomal structure during both non-selective and selective autophagy. Probably binds phosphatidylinositol 3-phosphate (PtdIns3P) which would mediate the recruitment preautophagosomal structures.
Protein Name Bcas3 Microtubule Associated Cell Migration Factor
Breast Carcinoma-Amplified Sequence 3
Gaob1
Cellular Localisation Nucleus
Cytoplasm
Cytoskeleton
Preautophagosomal Structure
Localizes In The Cytoplasm In Stationary Cells
Translocates From The Cytoplasm To The Leading Edge In Motile Cells
Colocalizes With Microtubules And Intermediate Filaments In Both Stationary And Motile Cells
Associates With Chromatin
Recruited To Estrogen Receptor-Induced Promoters In A Pelp1-Dependent Manner
The Bcas3:Phaf1 Complex Is Recruited To The Preautophagosomal Structures Adjacent To The Damaged Mitochondria Upon Mitophagy In A Prkn-Pink1 Dependent Manner
Alternative Protein Names Bcas3 Microtubule Associated Cell Migration Factor protein
Breast Carcinoma-Amplified Sequence 3 protein
Gaob1 protein
BCAS3 protein

Information sourced from Uniprot.org

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