Host: | E. coli |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description : | Recombinant-Human ASB9-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications. |
Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Gene Symbol: | ASB9 |
Gene ID: | 140462 |
Uniprot ID: | ASB9_HUMAN |
Immunogen Region: | Ser38-Leu294 |
Immunogen: | Homo sapiens (Human) |
Function | Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The ECS(ASB9) complex catalyzes ubiquitination of creatine kinases CKB and CKMT1A. Isoform 2: Does not interact with the Elongin BC complex, likely to be a negative regulator of isoform 1. |
Protein Name | Ankyrin Repeat And Socs Box Protein 9Asb-9 |
Database Links | Reactome: R-HSA-8951664Reactome: R-HSA-983168 |
Cellular Localisation | Mitochondrion |
Alternative Protein Names | Ankyrin Repeat And Socs Box Protein 9 proteinAsb-9 proteinASB9 protein |
Information sourced from Uniprot.org