Human API5 protein (Recombinant) (N-His) (STJP005964)

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STJP005964
£328.50 - £1,437.50
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human API5-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: API5
Gene ID: 8539
Uniprot ID: API5_HUMAN
Immunogen Region: Pro2-Phe360
Immunogen: Homo sapiens (Human)
Post Translational Modifications Acetylation at Lys-251 impairs antiapoptotic function.
Function Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.
Protein Name Apoptosis Inhibitor 5
Api-5
Antiapoptosis Clone 11 Protein
Aac-11
Cell Migration-Inducing Gene 8 Protein
Fibroblast Growth Factor 2-Interacting Factor
Fif
Protein Xagl
Cellular Localisation Nucleus
Cytoplasm
Mainly Nuclear
Can Also Be Cytoplasmic
Isoform 3: Cytoplasm
Alternative Protein Names Apoptosis Inhibitor 5 protein
Api-5 protein
Antiapoptosis Clone 11 Protein protein
Aac-11 protein
Cell Migration-Inducing Gene 8 Protein protein
Fibroblast Growth Factor 2-Interacting Factor protein
Fif protein
Protein Xagl protein
API5 protein
MIG8 protein

Information sourced from Uniprot.org

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