| Post Translational Modifications | N-glycosylated. Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. |
| Function | Catalyzes the oxidative deamination of primary amines to the corresponding aldehydes with the concomitant production of hydrogen peroxide and ammonia. Its preferred substrates are the diamines histamine and 1-methylhistamine and it could therefore play a role in allergic and immune responses. Has a broad specificity for diamines and can also act on cadaverine and putrescine, two products of amino acid catabolism. It could also act on polyamines, like spermidine and spermine though less efficiently, and regulate various biological processes. |
| Protein Name | Diamine Oxidase Copper-ContainingDiamine OxidaseAmiloride-Binding ProteinAmiloride-Binding Protein 1Amine Oxidase Copper Domain-Containing Protein 1HistaminaseKidney Amine OxidaseKaoKdao |
| Database Links | Reactome: R-HSA-211945Reactome: R-HSA-6798695 |
| Cellular Localisation | SecretedExtracellular SpaceCell MembranePeripheral Membrane ProteinExtracellular Side |
| Alternative Protein Names | Diamine Oxidase Copper-Containing proteinDiamine Oxidase proteinAmiloride-Binding Protein proteinAmiloride-Binding Protein 1 proteinAmine Oxidase Copper Domain-Containing Protein 1 proteinHistaminase proteinKidney Amine Oxidase proteinKao proteinKdao proteinAOC1 proteinABP proteinABP1 proteinDAO protein |
Information sourced from Uniprot.org
