Human ADAMTS4 (A Disintegrin And Metalloproteinase With Thrombospondin Motifs 4) Antibody Pair (STJAP00263)

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STJAP00263-50
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Host: Goat/Mouse
Applications: ELISA
Reactivity: Human
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description : This ADAMTS4 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA.
Clonality : Polyclonal/Monoclonal
Conjugation: Unconjugated/Biotin
Formulation: Capture Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.
Detection Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.
Purification: Capture Purification: Antigen Affinity.
Detection Purification: Protein A or G.
Concentration: 0.5 mg/mL
Storage Instruction: Store at-20°C for long term, and avoid freeze-thaw cycles.
Gene Symbol: ADAMTS4
Gene ID: 9507
Uniprot ID: ATS4_HUMAN
Immunogen: Capture immunogen: Recombinant Human ADAMTS4 protein.
Detection Immunogen: Recombinant Human ADAMTS4 protein.
Post Translational Modifications The precursor is cleaved by a furin endopeptidase. Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Can also be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion.
Function Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.
Protein Name A Disintegrin And Metalloproteinase With Thrombospondin Motifs 4
Adam-Ts 4
Adam-Ts4
Adamts-4
Admp-1
Aggrecanase-1
Database Links Reactome: R-HSA-1474228
Reactome: R-HSA-5083635
Reactome: R-HSA-5173214
Cellular Localisation Secreted
Extracellular Space
Extracellular Matrix
Alternative Antibody Pair Names A Disintegrin And Metalloproteinase With Thrombospondin Motifs 4 antibody pair
Adam-Ts 4 antibody pair
Adam-Ts4 antibody pair
Adamts-4 antibody pair
Admp-1 antibody pair
Aggrecanase-1 antibody pair
ADAMTS4 antibody pair
KIAA0688 antibody pair
UNQ769 antibody pair
PRO1563 antibody pair

Information sourced from Uniprot.org

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