Human ABCB11 protein (Recombinant) (N-His) (STJP003421)

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STJP003421
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human ABCB11-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: ABCB11
Gene ID: 8647
Uniprot ID: ABCBB_HUMAN
Immunogen Region: Glu421-Ala663
Immunogen: Homo sapiens (Human)
Post Translational Modifications N-glycosylated. Ubiquitinated.short-chain ubiquitination regulates cell-Surface expression of ABCB11.
Function Catalyzes the transport of the major hydrophobic bile salts, such as taurine and glycine-conjugated cholic acid across the canalicular membrane of hepatocytes in an ATP-dependent manner, therefore participates in hepatic bile acid homeostasis and consequently to lipid homeostasis through regulation of biliary lipid secretion in a bile salts dependent manner. Transports taurine-conjugated bile salts more rapidly than glycine-conjugated bile salts. Also transports non-bile acid compounds, such as pravastatin and fexofenadine in an ATP-dependent manner and may be involved in their biliary excretion.
Protein Name Bile Salt Export Pump
Atp-Binding Cassette Sub-Family B Member 11
Database Links Reactome: R-HSA-159418
Reactome: R-HSA-193368
Reactome: R-HSA-5678520
Cellular Localisation Apical Cell Membrane
Multi-Pass Membrane Protein
Recycling Endosome Membrane
Endosome
Cell Membrane
Internalized At The Canalicular Membrane Through Interaction With The Adapter Protein Complex 2 (Ap-2)
At Steady State
Localizes In The Canalicular Membrane But Is Also Present In Recycling Endosomes
Abcb11 Constantly And Rapidly Exchanges Between The Two Sites Through Tubulo-Vesicles Carriers That Move Along Microtubules
Microtubule-Dependent Trafficking Of Abcb11 Is Enhanced By Taurocholate And Camp And Regulated By Stk11 Through A Pka-Mediated Pathway
Trafficking Of Newly Synthesized Abcb11 Through Endosomal Compartment To The Bile Canalicular Membrane Is Accelerated By Camp But Not By Taurocholate
Cell Membrane Expression Is Up-Regulated By Short- And Medium-Chain Fatty Acids
Alternative Protein Names Bile Salt Export Pump protein
Atp-Binding Cassette Sub-Family B Member 11 protein
ABCB11 protein
BSEP protein

Information sourced from Uniprot.org