| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
EAAT1 Blocking Peptide is synthetically produced from the 475-550 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Slc1a3 |
| Gene ID: |
20512 |
| Uniprot ID: |
EAA1_MOUSE |
| Immunogen Region: |
475-550 |
| Immunogen: |
Synthetic peptide taken wtihin amino acid region 475-550 on mouse EAAT1 protein. |
| Tissue Specificity | Detected in brain, in Bergmann glia arborising into the molecular layer of the cerebellum (at protein level). Localized in brain and is highly enriched in the Purkinje cell layer in cerebellum. Intermediate level in lung, low level in spleen, skeletal muscle and testis. |
| Post Translational Modifications | Glycosylated. |
| Function | Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate. |
| Peptide Name | Excitatory Amino Acid Transporter 1Glial High Affinity Glutamate TransporterHigh-Affinity Neuronal Glutamate TransporterGlut-1Sodium-Dependent Glutamate/Aspartate Transporter 1Glast-1Solute Carrier Family 1 Member 3 |
| Database Links | Reactome: R-MMU-210455Reactome: -MMU-210500Reactome: -MMU-425393 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Peptide Names | Excitatory Amino Acid Transporter 1 proteinGlial High Affinity Glutamate Transporter proteinHigh-Affinity Neuronal Glutamate Transporter proteinGlut-1 proteinSodium-Dependent Glutamate/Aspartate Transporter 1 proteinGlast-1 proteinSolute Carrier Family 1 Member 3 proteinSlc1a3 proteinEaat1 proteinGmt1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
