Tissue Specificity | Isoform 1: Expressed in the anterior pituitary gland. Isoform 2: Expressed in the anterior pituitary gland. |
Post Translational Modifications | Palmitoylated. Palmitoylation which is required for proper localization to the plasma membrane and stability of the receptor could be carried on by ZDHHC4, ZDHHC3 and ZDHHC8. |
Function | Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5. |
Peptide Name | D(2 Dopamine ReceptorDopamine D2 Receptor |
Database Links | Reactome: R-HSA-390651 |
Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinGolgi Apparatus Membrane |
Alternative Peptide Names | D(2 Dopamine Receptor proteinDopamine D2 Receptor proteinDRD2 protein |
Information sourced from Uniprot.org