Trial size BIRC5 antibodies available in the Antibody Validation Project

Trial size BIRC5 antibodies available in the Antibody Validation Project

Posted by M.Popov on 12th Nov 2020

Trial size BIRC5 antibodies available in the Antibody Validation Project

Introduction:

Baculoviral IAP repeat containing 5 is a gene that encodes a protein responsible for cell proliferation and preventing apoptosis and participating in the chromosome passage protein complex. Mutations and overexpression of this protein can lead to brain, breast,gastric and several other types of cancer. We provide a number of trial sized antibodies, which are suitable for BIRC5 research purposes, and to help you make the right decision and find the best suited antibody for you, please find the answers to some of the key topics regarding BIRC5 that we have provided in the links below.

What is BIRC5?

This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death and usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain.It encodes a multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis, and also is a component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. The protein acts as an important regulator of the localization of this complex and directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. It is involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis.

Where is BIRC5 found?

BIRC5 is a protein which is normally expressed in embryonic tissues and during fetal development, as well as in fast dividing normal cells (like bone marrow stem cells, basal epithelial cells and thymocytes, even if at lower concentrations), but is virtually undetectable in fully differentiated and healthy adult tissues.  

What role does BIRC5 play in disease?

An elevated expression of BIRC5 protein has been found in almost all brain, breast, colorectal and gastric cancer. Estrogen positive breast cancer subtypes have been connected to increased BIRC5 regulation, which was reverted by treatment with the natural compound myricetin, enhancing apoptosis.

BIRC5 antibodies in the Antibody Validation project

St John's Laboratory offers a variety of trial size primary antibodies which target BIRC5, which are available to try through the Antibody Validation Project. Below we highlight those which have already been reviewed, as well as others which are available to try.

Customer reviewed BIRC5 antibodies

ModelNameHostClonalityRatingApplication Tested
STJ97436 Anti-Survivin antibody MouseMonoclonal4IF,IHC,WB

Other BIRC5 antibodies available in the Antibody Validation Project

ModelNameHostClonalityRecommended Applications
STJ90479Anti-Phospho-Survivin (T34) antibodyRabbitPolyclonalWB,ELISA
STJ91292Anti-Phospho-Survivin (T117) antibodyRabbitPolyclonalIHC,IF,ELISA
STJ95837Anti-Survivin antibodyRabbitPolyclonalIHC,ELISA
STJ95838Anti-Survivin antibodyRabbitPolyclonalWB,IHC,IF,ELISA
STJ97403Anti-Survivin antibodyRabbitPolyclonalIHC
STJ98403Anti-Survivin antibodyMouseMonoclonalWB,ELISA
ModelNameHostClonalityRecommended Applications
STJ112636Anti-BIRC5 AntibodyRabbitMonoclonalWB,IHC,IP
STJ180248Anti-BIRC5 antibodyRabbitMonoclonalIHC
STJ26172Anti-BIRC5 AntibodyRabbitPolyclonalWB,IF
STJ502705Anti-Phospho-Survivin AntibodyRabbitPolyclonalELISA,WB
STJ502706Anti-Phospho-Survivin Antibody BIOTINRabbitPolyclonalELISA,WB
STJ502707Anti-Phospho-Survivin Antibody FITCRabbitPolyclonalELISA,WB
STJ503165Anti-BIRC5 Antibody (Biotin)RabbitPolyclonalELISA,WB
STJ503166Anti-BIRC5 Antibody (FITC)RabbitPolyclonalELISA,WB

How does the Antibody Validation Project work?

In order to help our customers with their choice of antibody with low risk, we offer one of the largest ranges of primary antibodies with trial size options available.

The Antibody Validation Project works like this.
1. Order your trial size antibody online.
2. Explore its suitability.
3. Return your results by posting them on the product page.
4. Receive a sample refund.

Find out more here.

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