| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ZC3HAV1 (150-400) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ZC3HAV1 |
| Gene ID: |
56829 |
| Uniprot ID: |
ZCCHV_HUMAN |
| Immunogen Region: |
150-400 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 150-400 of human ZC3HAV1 (NP_078901.3). |
| Immunogen Sequence: |
CKSYKGEGRQQICNQQPPCS RLHICDHFTRGNCRFPNCLR SHNLMDRKVLAIMREHGLNP DVVQNIQDICNSKHMQKNPP GPRAPSSHRRNMAYRARSKS RDRFFQGSQEFLASASASAE RSCTPSPDQISHRASLEDAP VDDLTRKFTYLGSQDRARPP SGSSKATDLGGTSQAGTSQR FLENGSQEDLLHGNPGSTYL ASNSTSAPNWKSLTSWTNDQ GARRKTVFSPTLPAARSSL |
| Post Translational Modifications | Phosphorylation at Ser-275 is essential for sequential phosphorylation of Ser-271, Ser-267, Ser-263 and Ser-257 by GSK3-beta. Phosphorylation by GSK3-beta enhances its antiviral activity. |
| Function | Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). |
| Protein Name | Zinc Finger Ccch-Type Antiviral Protein 1Adp-Ribosyltransferase Diphtheria Toxin-Like 13Artd13Inactive Poly Adp-Ribose Polymerase 13Parp13Zinc Finger Ccch Domain-Containing Protein 2Zinc Finger Antiviral ProteinZap |
| Database Links | Reactome: R-HSA-6802952 |
| Cellular Localisation | Isoform 1: CytoplasmNucleusLocalizes In The Cytoplasm At Steady StateBut Shuttles Between Nucleus And Cytoplasm In A Xpo1-Dependent MannerIsoform 2: Cytoplasm |
| Alternative Antibody Names | Anti-Zinc Finger Ccch-Type Antiviral Protein 1 antibodyAnti-Adp-Ribosyltransferase Diphtheria Toxin-Like 13 antibodyAnti-Artd13 antibodyAnti-Inactive Poly Adp-Ribose Polymerase 13 antibodyAnti-Parp13 antibodyAnti-Zinc Finger Ccch Domain-Containing Protein 2 antibodyAnti-Zinc Finger Antiviral Protein antibodyAnti-Zap antibodyAnti-ZC3HAV1 antibodyAnti-ZC3HDC2 antibodyAnti-PRO1677 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
