| Post Translational Modifications | Ubiquitinated by RBBP6.leading to its degradation by the proteasome. |
| Function | Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to E-box elements (5'-CACGTG-3'). Can also bind specifically to a single methyl-CpG pair. Represses transcription in a methyl-CpG-dependent manner. Plays an important role in regulating DNA replication and common fragile sites (CFS) stability in a RBBP6- and MCM10-dependent manner.represses expression of MCM10 which plays an important role in DNA-replication. Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons. |
| Protein Name | Zinc Finger And Btb Domain-Containing Protein 38 |
| Cellular Localisation | NucleusChromosomeLocalizes To Chromocenters |
| Alternative Antibody Names | Anti-Zinc Finger And Btb Domain-Containing Protein 38 antibodyAnti-ZBTB38 antibody |
Information sourced from Uniprot.org
