| Tissue Specificity | Ubiquitously expressed at low levels. Expression is highest in skeletal muscle, heart, spleen and placenta. |
| Post Translational Modifications | Autosumoylated with SUMO1, SUMO2, and SUMO3. |
| Function | Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase which sumoylates CHD3/Mi2-alpha, causing its release from DNA. This results in suppression of CHD3/Mi2-alpha transcription repression, increased recruitment of RNA polymerase II to gene promoters and positive regulation of transcription including H1-5 and ribosomal proteins such as: RPS6, RPL10A, and RPL12. The resulting increased transcriptional activity drives cell proliferation. Binds to 5'-TGTCGCTGACTA-3' consensus sequences in gene promoters of ribosomal proteins. (Microbial infection) Binds to human adenovirus gene promoters and contributes to transcriptional repression and virus growth inhibition during early stages of infection. |
| Protein Name | E3 Sumo-Protein Ligase Zbed1Dna Replication-Related Element-Binding FactorPutative Ac-Like Transposable ElementZinc Finger Bed Domain-Containing Protein 1Dref Homolog |
| Database Links | Reactome: R-HSA-4551638 |
| Cellular Localisation | NucleusPml BodyIn Granular Structures(Microbial Infection) Upon Interaction With Human Adenovirus Early E1a ProteinThe Protein Is Redistributed To The Peripheral Areas Of Pml Bodies |
| Alternative Antibody Names | Anti-E3 Sumo-Protein Ligase Zbed1 antibodyAnti-Dna Replication-Related Element-Binding Factor antibodyAnti-Putative Ac-Like Transposable Element antibodyAnti-Zinc Finger Bed Domain-Containing Protein 1 antibodyAnti-Dref Homolog antibodyAnti-ZBED1 antibodyAnti-ALTE antibodyAnti-DREF antibodyAnti-hDREF antibodyAnti-KIAA0785 antibodyAnti-TRAMP antibody |
Information sourced from Uniprot.org
