| Post Translational Modifications | Ubiquitinated and degradaded by the proteasome during oocyte meiotic maturation, leading to MARDO (mitochondria-associated ribonucleoprotein domain) membraneless compartment dissolution. |
| Function | mRNA-binding protein that mediates formation of MARDO (mitochondria-associated ribonucleoprotein domain), a membraneless compartment that stores maternal mRNAs in oocytes. MARDO assembly around mitochondria is directed by an increase in mitochondrial membrane potential during oocyte growth. Promotes formation of MARDO phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to maternal mRNAs. Binds to the 3'-UTR of maternal mRNAs. Maternal mRNAs stored in the MARDO are translationally repressed. Essential for female fertility and oocyte-to-embryo transition by coordinating maternal mRNA storage, translation and degradation. |
| Protein Name | Zygote Arrest Protein 1 |
| Cellular Localisation | CytoplasmCytoplasmic Ribonucleoprotein GranuleSpecifically Localizes To Mardo (Mitochondria-Associated Ribonucleoprotein Domain)A Mitochondria-Associated Membraneless Compartment That Stores Mrnas In Oocytes |
| Alternative Antibody Names | Anti-Zygote Arrest Protein 1 antibodyAnti-ZAR1 antibody |
Information sourced from Uniprot.org
