| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | WNT3 |
| Gene ID: | 7473 |
| Uniprot ID: | WNT3_HUMAN |
| Immunogen Region: | 166-355 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 166-355 of human WNT3 (NP_110380.1). |
| Immunogen Sequence: | VLVSREFADARENRPDARSA MNKHNNEAGRTTILDHMHLK CKCHGLSGSCEVKTCWWAQP DFRAIGDFLKDKYDSASEMV VEKHRESRGWVETLRAKYSL FKPPTERDLVYYENSPNFCE PNPETGSFGTRDRTCNVTSH GIDGCDLLCCGRGHNTRTEK RKEKCHCIFHWCCYVSCQEC IRIYDVHTCK |
| Post Translational Modifications | Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition. |
| Function | Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. Required for normal gastrulation, formation of the primitive streak, and for the formation of the mesoderm during early embryogenesis. Required for normal formation of the apical ectodermal ridge. Required for normal embryonic development, and especially for limb development. |
| Protein Name | Proto-Oncogene Wnt-3Proto-Oncogene Int-4 Homolog |
| Database Links | Reactome: R-HSA-201681Reactome: R-HSA-3238698Reactome: R-HSA-373080 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Names | Anti-Proto-Oncogene Wnt-3 antibodyAnti-Proto-Oncogene Int-4 Homolog antibodyAnti-WNT3 antibodyAnti-INT4 antibody |
Information sourced from Uniprot.org