| Function | Required for selective macroautophagy (aggrephagy). Acts as an adapter protein by linking specific proteins destined for degradation to the core autophagic machinery members, such as the ATG5-ATG12-ATG16L E3-like ligase, SQSTM1 and LC3. Along with p62/SQSTM1, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with SQSTM1, required to recruit ubiquitinated proteins to PML bodies in the nucleus. Important for normal brain development. Essential for the formation of axonal tracts throughout the brain and spinal cord, including the formation of the major forebrain commissures. Involved in the ability of neural cells to respond to guidance cues. Required for cortical neurons to respond to the trophic effects of netrin-1/NTN1. Regulates Wnt signaling through the removal of DVL3 aggregates, likely in an autophagy-dependent manner. This process may be important for the determination of brain size during embryonic development. May regulate osteoclastogenesis by acting on the TNFSF11/RANKL - TRAF6 pathway. After cytokinetic abscission, involved in midbody remnant degradation. In vitro strongly binds to phosphatidylinositol 3-phosphate (PtdIns3P). |
| Protein Name | Wd Repeat And Fyve Domain-Containing Protein 3Autophagy-Linked Fyve ProteinAlfy |
| Cellular Localisation | Nucleus MembraneCytoplasmCytosolNucleusPml BodyMembranePeripheral Membrane ProteinCytoplasmic SidePerikaryonCell ProjectionAxonRelocalization From The Nucleus To The Cytosol Is Stimulated By Cellular StressSuch As Starvation Or Proteasomal InhibitionIn The Cytosol Of Starved CellsColocalizes With Autophagic StructuresThis Redistribution Is Dependent On P62/Sqstm1When Nuclear Export Is Blocked By Treatment With Leptomycin BAccumulates In Nuclear BodiesThat Completely Or Partially Colocalize With Promyelocytic Leukemia (Pml) BodiesLocalizes Throughout NeuronsIncluding Within AxonsIn NeuronsEnriched In The Light Membrane Fraction Along With The Synaptosomal Membrane Protein Synaptophysin And The Membrane-Bound Form Of Lc3/Map1lc3a/Map1lc3bCalled Lc3-IiA Classic Marker For Autophagic Vesicles |
| Alternative Antibody Names | Anti-Wd Repeat And Fyve Domain-Containing Protein 3 antibodyAnti-Autophagy-Linked Fyve Protein antibodyAnti-Alfy antibodyAnti-WDFY3 antibodyAnti-KIAA0993 antibody |
Information sourced from Uniprot.org
