Anti-VMAT1 antibody (STJ13100469)

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STJ13100469-100
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Host: Rabbit
Applications: WB/IHC
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-VMAT1 is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Lyophilised
Purification: IgG purified
Dilution Range: WB, IHC. A dilution of 1: 1000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Storage Instruction: Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Gene Symbol: SLC18A1
Gene ID: 6570
Uniprot ID: VMAT1_HUMAN
Specificity: Specific for VMAT1.
Immunogen: A synthetic peptide from human VMAT1 conjugated to blue carrier protein was used as the antigen. The peptides shares about 75% identity with mouse and rat sequences.
Function Isoform 1: Electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to accumulate high concentrations of monoamines inside the vesicles prior to their release via exocytosis. Transports catecholamines and indolamines with higher affinity for serotonin. Regulates the transvesicular monoaminergic gradient that determines the quantal size. Mediates presynaptic monoaminergic vesicle transport in the amygdala and prefrontal brain regions related with emotion processing in response to environmental stimuli. Isoform 2: Unable to uptake serotonin.
Protein Name Chromaffin Granule Amine Transporter
Solute Carrier Family 18 Member 1
Vesicular Amine Transporter 1
Vat1
Database Links Reactome: R-HSA-442660
Cellular Localisation Cytoplasmic Vesicle
Secretory Vesicle Membrane
Multi-Pass Membrane Protein
Secretory Vesicle
Synaptic Vesicle Membrane
Isoform 1: Cytoplasmic Vesicle
Isoform 2: Endoplasmic Reticulum Membrane
Alternative Antibody Names Anti-Chromaffin Granule Amine Transporter antibody
Anti-Solute Carrier Family 18 Member 1 antibody
Anti-Vesicular Amine Transporter 1 antibody
Anti-Vat1 antibody
Anti-SLC18A1 antibody
Anti-VAT1 antibody
Anti-VMAT1 antibody

Information sourced from Uniprot.org

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