| Function | Isoform 1: Electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to accumulate high concentrations of monoamines inside the vesicles prior to their release via exocytosis. Transports catecholamines and indolamines with higher affinity for serotonin. Regulates the transvesicular monoaminergic gradient that determines the quantal size. Mediates presynaptic monoaminergic vesicle transport in the amygdala and prefrontal brain regions related with emotion processing in response to environmental stimuli. Isoform 2: Unable to uptake serotonin. |
| Protein Name | Chromaffin Granule Amine TransporterSolute Carrier Family 18 Member 1Vesicular Amine Transporter 1Vat1 |
| Database Links | Reactome: R-HSA-442660 |
| Cellular Localisation | Cytoplasmic VesicleSecretory Vesicle MembraneMulti-Pass Membrane ProteinSecretory VesicleSynaptic Vesicle MembraneIsoform 1: Cytoplasmic VesicleIsoform 2: Endoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Chromaffin Granule Amine Transporter antibodyAnti-Solute Carrier Family 18 Member 1 antibodyAnti-Vesicular Amine Transporter 1 antibodyAnti-Vat1 antibodyAnti-SLC18A1 antibodyAnti-VAT1 antibodyAnti-VMAT1 antibody |
Information sourced from Uniprot.org
