| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Vesicle-associated membrane protein 1 (30-110 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | VAMP1 |
| Gene ID: | 6843 |
| Uniprot ID: | VAMP1_HUMAN |
| Immunogen Region: | 30-110 aa |
| Specificity: | VAMP1 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from the human protein at the amino acid range 30-110 |
| Post Translational Modifications | (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type B (BoNT/B, botB) which probably hydrolyzes the 78-Gln-|-Phe-79 bond and inhibits neurotransmitter release. (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type D (BoNT/D, botD) which probably hydrolyzes the 61-Arg-|-Leu-62 bond and inhibits neurotransmitter release. BoNT/D has low catalytic activity on this protein due to its sequence. Note that humans are not known to be infected by C.botulinum type D. (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type F (BoNT/F, botF) which probably hydrolyzes the 60-Gln-|-Lys-61 bond and inhibits neurotransmitter release. (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type X (BoNT/X) which probably hydrolyzes the 68-Arg-|-Ala-69 bond and inhibits neurotransmitter release. It remains unknown whether BoNT/X is ever produced, or what organisms it targets. |
| Function | Involved in the targeting and/or fusion of transport vesicles to their target membrane. |
| Protein Name | Vesicle-Associated Membrane Protein 1 Vamp-1 Synaptobrevin-1 |
| Database Links | Reactome: R-HSA-5250955 Reactome: R-HSA-5250981 Reactome: R-HSA-5250989 |
| Cellular Localisation | Isoform 1: Cytoplasmic Vesicle Secretory Vesicle Synaptic Vesicle Membrane Single-Pass Type Iv Membrane Protein Synapse Synaptosome Isoform 2: Cytoplasmic Vesicle Membrane Isoform 3: Mitochondrion Outer Membrane |
| Alternative Antibody Names | Anti-Vesicle-Associated Membrane Protein 1 antibody Anti-Vamp-1 antibody Anti-Synaptobrevin-1 antibody Anti-VAMP1 antibody Anti-SYB1 antibody |
Information sourced from Uniprot.org