Anti-ULK3 antibody (N-Term) (STJ13102592)

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STJ13102592-150
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Host: Rabbit
Applications: IHC/WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-ULK3 (N-Term) is suitable for use in Immunohistochemistry and Western Blot research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Lyophilised
Purification: IgG purified
Dilution Range: IHC, WB. Use at a dilution of 1:200 to 1:2000. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Storage Instruction: Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Gene Symbol: ULK3
Gene ID: 25989
Uniprot ID: ULK3_HUMAN
Immunogen Region: N-Term
Specificity: Specific for ULK3.
Immunogen: A synthetic peptide from the n-terminal of human ULK3 conjugated to an immunogenic carrier protein has been used as the antigen. The peptide is identical in mouse.
Post Translational Modifications Autophosphorylated. Autophosphorylation is blocked by interaction with SUFU.
Function Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.
Protein Name Serine/Threonine-Protein Kinase Ulk3
Unc-51-Like Kinase 3
Database Links Reactome: R-HSA-5632684
Cellular Localisation Cytoplasm
Localizes To Pre-Autophagosomal Structure During Cellular Senescence
Alternative Antibody Names Anti-Serine/Threonine-Protein Kinase Ulk3 antibody
Anti-Unc-51-Like Kinase 3 antibody
Anti-ULK3 antibody

Information sourced from Uniprot.org

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