| Post Translational Modifications | Autophosphorylated. In response to nutrient limitation, probably phosphorylated and activated by AMPK, leading to activate autophagy. |
| Function | Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR.however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons. |
| Protein Name | Serine/Threonine-Protein Kinase Ulk2Unc-51-Like Kinase 2 |
| Cellular Localisation | Cytoplasmic Vesicle MembranePeripheral Membrane ProteinLocalizes To Pre-Autophagosomal Membrane |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Ulk2 antibodyAnti-Unc-51-Like Kinase 2 antibodyAnti-ULK2 antibodyAnti-KIAA0623 antibody |
Information sourced from Uniprot.org
