| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-UBR4 (4884-5183) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
UBR4 |
| Gene ID: |
23352 |
| Uniprot ID: |
UBR4_HUMAN |
| Immunogen Region: |
4884-5183 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 4884-5183 of human UBR4 (NP_065816.2). |
| Immunogen Sequence: |
NIVHYDCHLAAVRLARGREE WESAALQNANTKCNGLLPVW GPHVPESAFATCLARHNTYL QECTGQREPTYQLNIHDIKL LFLRFAMEQSFSADTGGGGR ESNIHLIPYIIHTVLYVLNT TRATSREEKNLQGFLEQPKE KWVESAFEVDGPYYFTVLAL HILPPEQWRATRVEILRRLL VTSQARAVAPGGATRLTDKA VKDYSAYRSSLLFWALVDLI YNMFKKVPTSNTEGGWSCS |
| Function | E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation. |
| Protein Name | E3 Ubiquitin-Protein Ligase Ubr4600 Kda Retinoblastoma Protein-Associated FactorN-Recognin-4Ring-Type E3 Ubiquitin Transferase Ubr4Retinoblastoma-Associated Factor Of 600 KdaRbaf600P600Zinc Finger Ubr1-Type Protein 1 |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-983168 |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinCytoplasmCytoskeletonNucleusConcentrates At The Leading Edge Of Membrane Structures Involved In Actin Motility |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Ubr4 antibodyAnti-600 Kda Retinoblastoma Protein-Associated Factor antibodyAnti-N-Recognin-4 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Ubr4 antibodyAnti-Retinoblastoma-Associated Factor Of 600 Kda antibodyAnti-Rbaf600 antibodyAnti-P600 antibodyAnti-Zinc Finger Ubr1-Type Protein 1 antibodyAnti-UBR4 antibodyAnti-KIAA0462 antibodyAnti-KIAA1307 antibodyAnti-RBAF600 antibodyAnti-ZUBR1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
