| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
Ubn1 |
| Gene ID: |
170644 |
| Uniprot ID: |
UBN1_MOUSE |
| Immunogen Region: |
1000-1100 aa |
| Specificity: |
A synthetic peptide corresponding to a sequence within amino acids 1000-1100 of mouse UBN1 (NP_080942.1). |
| Immunogen Sequence: |
SVTSSTSLPKGTGGAVLLSN TSSLSLLSSSYKSNNPKLPG AMNSNSLGIITQFPLHVLSF NADSSAKAGVSKDAIVTGPA PGTFHHGLSHSLLAGLHSSP P |
| Tissue Specificity | Expressed in bile canaliculi in liver, in bronchiolar epithelium in lung and in tubular structures of gland ducts inside the olfactory epithelium and tongue epithelium. |
| Function | Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly. |
| Protein Name | Ubinuclein-1Ubiquitously Expressed Nuclear Protein |
| Database Links | Reactome: R-MMU-2559584 |
| Cellular Localisation | NucleusNucleoplasmPml BodyCell JunctionTight JunctionLocalized As A Nuclear Speckled-Like Pattern In Proliferating Primary FibroblastsColocalizes With HiraPml And Sp100 In Pml Bodies Of Senescent CellsColocalizes With Cldn1Detected Along The Upper Granular Cell Layer Of EpidermisWhen OverexpressedAccumulates In The Nucleus In Cells Showing Defective CytokinesisColocalizes With Tjp1 |
| Alternative Antibody Names | Anti-Ubinuclein-1 antibodyAnti-Ubiquitously Expressed Nuclear Protein antibodyAnti-Ubn1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
