| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | UBLCP1 |
| Gene ID: | 134510 |
| Uniprot ID: | UBCP1_HUMAN |
| Immunogen Region: | 99-318 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 99-318 of human UBLCP1 (NP_659486.2). |
| Immunogen Sequence: | FDIEDEVVEVENREENLLKI SRRVKEYKVEILNPPREGKK LLVLDVDYTLFDHRSCAETG VELMRPYLHEFLTSAYEDYD IVIWSATNMKWIEAKMKELG VSTNANYKITFMLDSAAMIT VHTPRRGLIDVKPLGVIWGK FSEFYSKKNTIMFDDIGRNF LMNPQNGLKIRPFMKAHLNR DKDKELLKLTQYLKEIAKLD DFLDLNHKYWERYLSKKQGQ |
| Tissue Specificity | Broadly expressed, with highest levels in placenta, lung, testis and ovary. Up-regulated in tumor tissues. |
| Function | Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. Recruited to the 19S regulatory particle of the 26S proteasome through its interaction with 19S component PSMD2/RPN1. Once recruited, dephosphorylates 19S component PSMC2/RPT1 which impairs PSMC2 ATPase activity and disrupts 26S proteasome assembly. Has also been reported to stimulate the proteolytic activity of the 26S proteasome. |
| Protein Name | Ubiquitin-Like Domain-Containing Ctd Phosphatase 1Nuclear Proteasome Inhibitor Ublcp1 |
| Cellular Localisation | NucleusColocalizes With Nuclear Proteasomes |
| Alternative Antibody Names | Anti-Ubiquitin-Like Domain-Containing Ctd Phosphatase 1 antibodyAnti-Nuclear Proteasome Inhibitor Ublcp1 antibodyAnti-UBLCP1 antibody |
Information sourced from Uniprot.org