![Anti-Ube2N/Ubc13 antibody [SM5128] (STJA0005128)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/180181/403618/STJA0005128_1__27833.1738950626.png?c=1 "Anti-Ube2N/Ubc13 antibody [SM5128] (STJA0005128)")
![Anti-Ube2N/Ubc13 antibody [SM5128] (STJA0005128)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/180181/403618/STJA0005128_1__27833.1738950626.png?c=1 "Anti-Ube2N/Ubc13 antibody [SM5128] (STJA0005128)")
| Host: | Mouse |
| Applications: | WB |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-Ube2N/Ubc13 is suitable for use in Western Blot research applications. |
| Clonality : | Monoclonal |
| Clone ID : | SM5128 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% sodium azide, 100 Mu g/ml BSA and 50% glycerol. |
| Purification: | Affinity purification |
| Dilution Range: | WB (M, R) 1:1000-1:2000 |
| Storage Instruction: | Store at-20C for up to one year, and avoid repeated freeze-thaw cycles. |
| Gene Symbol: | Ube2n |
| Gene ID: | 93765 |
| Uniprot ID: | UBE2N_MOUSE |
| Immunogen: | Recombinant protein corresponding to Mouse Ubc13 |
| Function | The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. Together with RNF135 and UB2V1, catalyzes the RNA-dependent 'Lys-63'-linked polyubiquitination of RIGI to activate the downstream signaling pathway that leads to interferon beta production. UBE2V1-UBE2N together with TRAF3IP2 E3 ubiquitin ligase mediate 'Lys-63'-linked polyubiquitination of TRAF6, a component of IL17A-mediated signaling pathway. |
| Protein Name | Ubiquitin-Conjugating Enzyme E2 NBendless-Like Ubiquitin-Conjugating EnzymeE2 Ubiquitin-Conjugating Enzyme NUbc13Ubiquitin Carrier Protein NUbiquitin-Protein Ligase N |
| Database Links | Reactome: R-MMU-1169408Reactome: -MMU-168638Reactome: -MMU-202424Reactome: -MMU-2871837Reactome: -MMU-445989Reactome: -MMU-450302Reactome: -MMU-450321Reactome: -MMU-5205685Reactome: -MMU-5607764Reactome: -MMU-5693565Reactome: -MMU-5693571Reactome: -MMU-5693607Reactome: -MMU-5696395Reactome: -MMU-69473Reactome: -MMU-8866654Reactome: -MMU-9020702Reactome: -MMU-937039Reactome: -MMU-937041Reactome: -MMU-9646399Reactome: -MMU-975144Reactome: -MMU-983168 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Ubiquitin-Conjugating Enzyme E2 N antibodyAnti-Bendless-Like Ubiquitin-Conjugating Enzyme antibodyAnti-E2 Ubiquitin-Conjugating Enzyme N antibodyAnti-Ubc13 antibodyAnti-Ubiquitin Carrier Protein N antibodyAnti-Ubiquitin-Protein Ligase N antibodyAnti-Ube2n antibodyAnti-Blu antibody |
Information sourced from Uniprot.org
