| Tissue Specificity | Isoform 2 is widely expressed. Isoform 3 is highly expressed in heart, brain and lung, lower expressed in thymus and much lower expressed in peripheral blood leukocytes. |
| Function | RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation.an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site. Shows a preference for AGC or AGA. |
| Protein Name | Splicing Factor U2af 26 Kda SubunitU2 Auxiliary Factor 26U2 Small Nuclear Rna Auxiliary Factor 1-Like Protein 4U2af1-Like 4U2(Rnu2 Small Nuclear Rna Auxiliary Factor 1-Like Protein 3U2 Small Nuclear Rna Auxiliary Factor 1-Like Protein 3U2af1-Like Protein 3 |
| Database Links | Reactome: R-HSA-159236Reactome: R-HSA-72163Reactome: R-HSA-72187Reactome: R-HSA-73856 |
| Cellular Localisation | NucleusNucleus SpeckleCytoplasmInteraction With C1qbp Is Required For The Nuclear TranslocationDisplays Active Nucleo-Cytoplasmic Shuttling |
| Alternative Antibody Names | Anti-Splicing Factor U2af 26 Kda Subunit antibodyAnti-U2 Auxiliary Factor 26 antibodyAnti-U2 Small Nuclear Rna Auxiliary Factor 1-Like Protein 4 antibodyAnti-U2af1-Like 4 antibodyAnti-U2(Rnu2 Small Nuclear Rna Auxiliary Factor 1-Like Protein 3 antibodyAnti-U2 Small Nuclear Rna Auxiliary Factor 1-Like Protein 3 antibodyAnti-U2af1-Like Protein 3 antibodyAnti-U2AF1L4 antibodyAnti-U2AF1-RS3 antibodyAnti-U2AF1L3 antibody |
Information sourced from Uniprot.org
