| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TXNRD2 |
| Gene ID: | 10587 |
| Uniprot ID: | TRXR2_HUMAN |
| Immunogen Region: | 100-310 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 100-310 of human Thioredoxin reductase 2 (Thioredoxin reductase 2 (TXNRD2 ) ) (NP_006431.2). |
| Immunogen Sequence: | AALLGGLIQDAPNYGWEVAQ PVPHDWRKMAEAVQNHVKSL NWGHRVQLQDRKVKYFNIKA SFVDEHTVCGVAKGGKEILL SADHIIIATGGRPRYPTHIE GALEYGITSDDIFWLKESPG KTLVVGASYVALECAGFLTG IGLDTTIMMRSIPLRGFDQQ MSSMVIEHMASHGTRFLRGC APSRVRRLPDGQLQVTWEDS TTGKEDTGTFD |
| Tissue Specificity | Highly expressed in the prostate, ovary, liver, testis, uterus, colon and small intestine. Intermediate levels in brain, skeletal muscle, heart and spleen. Low levels in placenta, pancreas, thymus and peripheral blood leukocytes. high levels in kidney, whereas levels are low. High expression is observed in the adrenal cortex. |
| Function | Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis. Maintains thioredoxin in a reduced state. May play a role in redox-regulated cell signaling. |
| Protein Name | Thioredoxin Reductase 2 - MitochondrialSelenoprotein ZSelzTr-BetaThioredoxin Reductase Tr3 |
| Database Links | Reactome: R-HSA-3299685 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Thioredoxin Reductase 2 - Mitochondrial antibodyAnti-Selenoprotein Z antibodyAnti-Selz antibodyAnti-Tr-Beta antibodyAnti-Thioredoxin Reductase Tr3 antibodyAnti-TXNRD2 antibodyAnti-KIAA1652 antibodyAnti-TRXR2 antibody |
Information sourced from Uniprot.org