| Function | Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro. Phosphorylates MPHOSPH9 which promotes its ubiquitination and proteasomal degradation, loss of MPHOSPH9 facilitates the removal of the CP110-CEP97 complex (a negative regulator of ciliogenesis) from the mother centrioles, promoting the initiation of ciliogenesis. Required for recruitment of CPLANE2 and INTU to the mother centriole. |
| Protein Name | Tau-Tubulin Kinase 2 |
| Database Links | Reactome: R-HSA-5620912 |
| Cellular Localisation | Cell ProjectionCiliumCytoplasmCytoskeletonCilium Basal BodyMicrotubule Organizing CenterCentrosomeCentrioleCytosolNucleusLocalizes At The Transition ZoneA Region Between The Basal Body And The Ciliary AxonemeMay Also Be Present In Cytosol AndAt Lower Level In The Nucleus |
| Alternative Antibody Names | Anti-Tau-Tubulin Kinase 2 antibodyAnti-TTBK2 antibodyAnti-KIAA0847 antibody |
Information sourced from Uniprot.org
