| Tissue Specificity | Ubiquitously expressed in adult tissues. Expressed in the postmitotic epithelial compartment at the top of intestinal mucosal villi. |
| Function | Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter. Acts to promote CASP3-mediated apoptosis. Positively regulates TGF-beta signaling by interacting with SMAD7 which inhibits binding of SMAD7 to TGFBR1, preventing recruitment of SMURF ubiquitin ligases to TGFBR1 and inhibiting SMURF-mediated ubiquitination and degradation of TGFBR1. Contributes to enhancement of TGF-beta signaling by binding to and modulating the transcription activator activity of SMAD4. Promotes TGF-beta-induced transcription of COL1A2.via its interaction with TFE3 at E-boxes in the gene proximal promoter. Plays a role in the repression of hematopoietic precursor cell growth. Promotes IL2 deprivation-induced apoptosis in T-lymphocytes, via repression of TSC22D3/GILZ transcription and activation of the caspase cascade. Isoform 1: May act to negatively regulate TGFB3 signaling and thereby inhibit cell death in mammary gland cells. Isoform 2: Positively regulates cell death in response to TGFB3 during mammary gland involution. |
| Protein Name | Tsc22 Domain Family Protein 1Cerebral Protein 2Hucep-2Regulatory Protein Tsc-22Tgfb-Stimulated Clone 22 HomologTransforming Growth Factor Beta-1-Induced Transcript 4 Protein |
| Cellular Localisation | CytoplasmNucleusCell MembranePeripheral Membrane ProteinIsoform 1: CytoplasmMitochondrionIsoform 2: CytoplasmIsoform 5: Cytoplasm |
| Alternative Antibody Names | Anti-Tsc22 Domain Family Protein 1 antibodyAnti-Cerebral Protein 2 antibodyAnti-Hucep-2 antibodyAnti-Regulatory Protein Tsc-22 antibodyAnti-Tgfb-Stimulated Clone 22 Homolog antibodyAnti-Transforming Growth Factor Beta-1-Induced Transcript 4 Protein antibodyAnti-TSC22D1 antibodyAnti-KIAA1994 antibodyAnti-TGFB1I4 antibodyAnti-TSC22 antibodyAnti-hucep-2 antibody |
Information sourced from Uniprot.org
