| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TRUB2 (122-331) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TRUB2 |
| Gene ID: |
26995 |
| Uniprot ID: |
TRUB2_HUMAN |
| Immunogen Region: |
122-331 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 122-331 of human TRUB2 (NP_056494.1). |
| Immunogen Sequence: |
AHLTKDYTVRGLLGKATDDF REDGRLVEKTTYDHVTREKL DRILAVIQGSHQKALVMYSN LDLKTQEAYEMAVRGLIRPM NKSPMLITGIRCLYFAPPEF LLEVQCMHETQKELRKLVHE IGLELKTTAVCTQVRRTRDG FFTLDSALLRTQWDLTNIQD AIRAATPQVAAELEKSLSPG LDTKQLPSPGWSWDSQGPSS TLGLERGAGQ |
| Function | Minor enzyme contributing to the isomerization of uridine to pseudouridine (pseudouridylation) of specific mitochondrial mRNAs (mt-mRNAs) such as COXI and COXIII mt-mRNAs. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation. Also catalyzes pseudouridylation of some tRNAs, including synthesis of pseudouridine(55) from uracil-55, in the psi GC loop of a subset of tRNAs. |
| Protein Name | Pseudouridylate Synthase Trub2 - MitochondrialTrub Pseudouridine Synthase Homolog 2Trna Pseudouridine 55 Synthase Trub2Psi55 Synthase Trub2 |
| Cellular Localisation | Mitochondrion MatrixLocalizes To Mitochondrial Rna GranulesPlatforms For Post-Transcriptional Rna Modification And Ribosome Assembly |
| Alternative Antibody Names | Anti-Pseudouridylate Synthase Trub2 - Mitochondrial antibodyAnti-Trub Pseudouridine Synthase Homolog 2 antibodyAnti-Trna Pseudouridine 55 Synthase Trub2 antibodyAnti-Psi55 Synthase Trub2 antibodyAnti-TRUB2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
