| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TRIM37 (735-964) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TRIM37 |
| Gene ID: |
4591 |
| Uniprot ID: |
TRI37_HUMAN |
| Immunogen Region: |
735-964 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 735-964 of human TRIM37 (NP_001005207.1). |
| Immunogen Sequence: |
LGMELLAKSSVANCYIRNST NKKSNSPKPARSSVAGSLSL RRAVDPGENSRSKGDCQTLS EGSPGSSQSGSRHSSPRALI HGSIGDILPKTEDRQCKALD SDAVVVAVFSGLPAVEKRRK MVTLGANAKGGHLEGLQMTD LENNSETGELQPVLPEGASA APEEGMSSDSDIECDTENEE QEEHTSVGGFHDSFMVMTQP PDEDTHSSFPDGEQIGPEDL SFNTDENSGR |
| Tissue Specificity | Ubiquitous. Highly expressed in testis, while it is weakly expressed in other tissues. |
| Post Translational Modifications | Auto-ubiquitinated. |
| Function | E3 ubiquitin-protein ligase required to prevent centriole reduplication. Probably acts by ubiquitinating positive regulators of centriole reduplication. Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes. Also acts as a positive regulator of peroxisome import by mediating monoubiquitination of PEX5 at 'Lys-472': monoubiquitination promotes PEX5 stabilitation by preventing its polyubiquitination and degradation by the proteasome. Has anti-HIV activity. |
| Protein Name | E3 Ubiquitin-Protein Ligase Trim37Mulibrey Nanism ProteinRing-Type E3 Ubiquitin Transferase Trim37Tripartite Motif-Containing Protein 37 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | ChromosomeCytoplasmPerinuclear RegionPeroxisome MembranePeripheral Membrane ProteinFound In Vesicles Of The PeroxisomeAggregates As AggresomesA Perinuclear Region Where Certain Misfolded Or Aggregated Proteins Are Sequestered For Proteasomal Degradation |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Trim37 antibodyAnti-Mulibrey Nanism Protein antibodyAnti-Ring-Type E3 Ubiquitin Transferase Trim37 antibodyAnti-Tripartite Motif-Containing Protein 37 antibodyAnti-TRIM37 antibodyAnti-KIAA0898 antibodyAnti-MUL antibodyAnti-POB1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
