| Post Translational Modifications | Phosphorylation at Ser-99 regulates the E3 ubiquitin-protein ligase activity but not the SUMO1-protein ligase activity. Phosphorylation at Ser-718 increases the E3 ubiquitin-protein ligase activity versus the E3 SUMO1-protein ligase activity resulting in increased p53/TP53 ubiquitination and degradation. Sumoylated. |
| Function | Functions as an E3 ubiquitin-protein ligase and as a E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA-damage-induced cell death through IKBKE sumoylation. |
| Protein Name | E3 Ubiquitin-Protein Ligase ToporsRing-Type E3 Ubiquitin Transferase ToporsSumo1-Protein E3 Ligase ToporsTopoisomerase I-Binding Ring Finger ProteinTopoisomerase I-Binding Arginine/Serine-Rich ProteinTumor Suppressor P53-Binding Protein 3P53-Binding Protein 3P53bp3 |
| Database Links | Reactome: R-MMU-3899300Reactome: -MMU-4085377Reactome: -MMU-4755510 |
| Cellular Localisation | NucleusPml BodyLocalizes To Discrete Nuclear Foci Which Partly Overlap With Pml Nuclear BodiesTargeted To Pml Nuclear Bodies Upon Dna Damage |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Topors antibodyAnti-Ring-Type E3 Ubiquitin Transferase Topors antibodyAnti-Sumo1-Protein E3 Ligase Topors antibodyAnti-Topoisomerase I-Binding Ring Finger Protein antibodyAnti-Topoisomerase I-Binding Arginine/Serine-Rich Protein antibodyAnti-Tumor Suppressor P53-Binding Protein 3 antibodyAnti-P53-Binding Protein 3 antibodyAnti-P53bp3 antibodyAnti-Topors antibody |
Information sourced from Uniprot.org
