| Tissue Specificity | Isoform 1 is found in testis, heart and skeletal muscle. A 4 kb transcript which probably represents isoform 2 is found in thymus, kidney and pancreas. |
| Function | Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. Possesses negatively supercoiled DNA relaxing activity. |
| Protein Name | Dna Topoisomerase 3-Beta-1Dna Topoisomerase Iii Beta-1 |
| Alternative Antibody Names | Anti-Dna Topoisomerase 3-Beta-1 antibodyAnti-Dna Topoisomerase Iii Beta-1 antibodyAnti-TOP3B antibodyAnti-TOP3B1 antibody |
Information sourced from Uniprot.org
