| Tissue Specificity | Predominantly expressed in the spleen but also found in the brain. Weakly expressed in peripheral lymphoid tissues and in heart, placenta, liver, lung, appendix, and kidney, and no expression seen in fetal tissues, endocrine glands, or nonhematopoietic tumor lines. |
| Post Translational Modifications | N-glycosylated. The soluble form of isoform 1 derives from the membrane form by proteolytic processing. |
| Function | Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Acts as a ligand for TNFRSF14/HVEM. Upon binding to TNFRSF14/HVEM, delivers costimulatory signals to T cells, leading to T cell proliferation and IFNG production. |
| Protein Name | Tumor Necrosis Factor Ligand Superfamily Member 14Herpes Virus Entry Mediator LigandHvem-LHerpesvirus Entry Mediator LigandCd Antigen Cd258 Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 14 - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 14 - Soluble Form |
| Database Links | Reactome: R-HSA-5668541Reactome: R-HSA-5669034Reactome: R-HSA-5676594 |
| Cellular Localisation | Tumor Necrosis Factor Ligand Superfamily Member 14Membrane Form: Cell MembraneSingle-Pass Type Ii Membrane ProteinSoluble Form: SecretedIsoform 2: Cytoplasm |
| Alternative Antibody Names | Anti-Tumor Necrosis Factor Ligand Superfamily Member 14 antibodyAnti-Herpes Virus Entry Mediator Ligand antibodyAnti-Hvem-L antibodyAnti-Herpesvirus Entry Mediator Ligand antibodyAnti-Cd Antigen Cd258 Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 14 - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 14 - Soluble Form antibodyAnti-TNFSF14 antibodyAnti-HVEML antibodyAnti-LIGHT antibodyAnti-UNQ391 antibodyAnti-PRO726 antibody |
Information sourced from Uniprot.org
