| Tissue Specificity | Highly expressed in adrenal gland, thyroid gland, testis, ovary and prostate. Moderate expression in trachea, spinal cord, stomach, colon, small intestine and spleen. Low expression in bone marrow, lymph node, thymus and peripheral blood lymphocytes. Expression is detected in hematopoietic cell lines including those of myeloid, erythroid, B- and T-cell origin. |
| Post Translational Modifications | N-glycosylated. |
| Function | Transmembrane protein that binds to and facilitates the assembly of lysosomal proton-transporting V-type ATPase (v-ATPase), resulting in enhanced lysosomal acidification and trafficking. By bringing the v-ATPase accessory protein ATP6AP2 and the v-ATPase subunit ATP6V0D1 together, allows v-ATPase complex formation and activation. TMEM9-controlled vesicular acidification induces hyperactivation of Wnt/beta-catenin signaling, involved in development, tissue homeostasis and tissue regeneration, through lysosomal degradation of adenomatous polyposis coli/APC. In the liver, involved in hepatic regeneration. |
| Protein Name | Proton-Transporting V-Type Atpase Complex Assembly Regulator Tmem9V-Atpase Assembly Regulator Tmem9Dermal Papilla-Derived Protein 4Transmembrane Protein 9Protein Tmem9 |
| Cellular Localisation | Lysosome MembraneSingle-Pass Type I Membrane ProteinLate Endosome MembraneEndosomeMultivesicular Body Membrane |
| Alternative Antibody Names | Anti-Proton-Transporting V-Type Atpase Complex Assembly Regulator Tmem9 antibodyAnti-V-Atpase Assembly Regulator Tmem9 antibodyAnti-Dermal Papilla-Derived Protein 4 antibodyAnti-Transmembrane Protein 9 antibodyAnti-Protein Tmem9 antibodyAnti-TMEM9 antibodyAnti-DERP4 antibodyAnti-TMEM9A antibodyAnti-HSPC186 antibodyAnti-PSEC0012 antibodyAnti-UNQ631 antibodyAnti-PRO1248 antibody |
Information sourced from Uniprot.org
