| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TMEM70 |
| Gene ID: | 54968 |
| Uniprot ID: | TMM70_HUMAN |
| Immunogen Region: | 161-260 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 161-260 of human TMEM70 (NP_060336.3). |
| Immunogen Sequence: | FITKGYVIRLYHEATTDTYK AITYNAMLAETSTVFHQNDV KIPDAKHVFTTFYAKTKSLL VNPVLFPNREDYIHLMGYDK EEFILYMEETSEEKRHKDDK |
| Tissue Specificity | Lower expressed in the heart than in the liver (at protein level). |
| Function | Scaffold protein that participates in the c-ring assembly of mitochondrial ATP synthase (F(1)F(0) ATP synthase or complex V) by facilitating the membrane insertion and oligomer formation of the subunit c/ATP5MC1 through its interaction. Therefore, participates in the early stage of mitochondrial ATP synthase biogenesis and also protects subunit c/ATP5MC1 against intramitochondrial proteolysis. In addition, binds the mitochondrial proton-transporting ATP synthase complexes I and may play a role in the stability of its membrane-bound subassemblies. |
| Protein Name | Transmembrane Protein 70 - Mitochondrial |
| Cellular Localisation | Mitochondrion Inner MembraneMulti-Pass Membrane ProteinMostly Located Within The Inner Cristae Membrane |
| Alternative Antibody Names | Anti-Transmembrane Protein 70 - Mitochondrial antibodyAnti-TMEM70 antibody |
Information sourced from Uniprot.org