| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TMEFF2 (41-320) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TMEFF2 |
| Gene ID: |
23671 |
| Uniprot ID: |
TEFF2_HUMAN |
| Immunogen Region: |
41-320 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 41-320 of human TMEFF2 (NP_057276.2). |
| Immunogen Sequence: |
FPTSLSDCQTPTGWNCSGYD DRENDLFLCDTNTCKFDGEC LRIGDTVTCVCQFKCNNDYV PVCGSNGESYQNECYLRQAA CKQQSEILVVSEGSCATDAG SGSGDGVHEGSGETSQKETS TCDICQFGAECDEDAEDVWC VCNIDCSQTNFNPLCASDGK SYDNACQIKEASCQKQEKIE VMSLGRCQDNTTTTTKSEDG HYARTDYAENANKLEESARE HHIPCPEHYNGFCMHGKCE |
| Tissue Specificity | Highly expressed in adult and fetal brain, spinal cord and prostate. Expressed in all brain regions except the pituitary gland, with highest levels in amygdala and corpus callosum. Expressed in the pericryptal myofibroblasts and other stromal cells of normal colonic mucosa. Expressed in prostate carcinoma. Down-regulated in colorectal cancer. Present in Alzheimer disease plaques (at protein level). Isoform 3 is expressed weakly in testis and at high levels in normal and cancerous prostate. |
| Post Translational Modifications | O-glycosylated.contains chondroitin sulfate glycosaminoglycans. A soluble form (TMEFF2-ECD) is produced by proteolytic shedding. This shedding can be induced by phorbol ester or pro-inflammatory cytokines such as TNFalpha, and is mediated by ADAM17. |
| Function | May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation. |
| Protein Name | Tomoregulin-2Tr-2Hyperplastic Polyposis Protein 1Transmembrane Protein With Egf-Like And Two Follistatin-Like Domains |
| Cellular Localisation | Isoform 1: MembraneSingle-Pass Type I Membrane ProteinIsoform 2: MembraneIsoform 3: Secreted |
| Alternative Antibody Names | Anti-Tomoregulin-2 antibodyAnti-Tr-2 antibodyAnti-Hyperplastic Polyposis Protein 1 antibodyAnti-Transmembrane Protein With Egf-Like And Two Follistatin-Like Domains antibodyAnti-TMEFF2 antibodyAnti-HPP1 antibodyAnti-TENB2 antibodyAnti-TPEF antibodyAnti-UNQ178 antibodyAnti-PRO204 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Immunofluorescence analysis of PC-12 cells using [KO Validated] KEAP1 Rabbit polyclonal antibody (STJ11104499) at dilution of 1:100 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/177143/368561/STJ11104499_1__57159.1713134043.jpg?c=1 "Immunofluorescence analysis of PC-12 cells using [KO Validated] KEAP1 Rabbit polyclonal antibody (STJ11104499) at dilution of 1:100 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.")
