| Background | The T cell intracellular antigen 1 (TIA‐1) is a 17‐kDa cytoplasmic granule associated protein also designated as GMP‐17, for granule membrane protein of 17 kDa. The GMP‐ 17/TIA‐1 molecule is expressed in cells possessing cytolytic potential and could be involved in the signaling cascade of Fas (CD95) ‐mediated apoptosis. Within hematopoietic cell lines, the 2G9 monoclonal antibody (mAb) reacts with about 90% of CD16+, 50 – 60% of CD8+, and less than 10% of CD4+ normal peripheral blood lymphocytes. It reacts with almost all monocytes and granulocytes. This antibody also reacts with CD4+ activated T‐cell clones, activated NK cell clones, and Con activated thymocytes, but not with B lymphocytes or B‐cell lines. |
| Database Links | Reactome: R-HSA-6803529 |
| Cellular Localisation | CytoplasmStress GranuleNucleusAccumulates In Cytoplasmic Stress Granules (Sg) Following Cellular Damage |
| Protein Name | Nucleolysin Tia-1 Isoform P40Rna-Binding Protein Tia-1T-Cell-Restricted Intracellular Antigen-1Tia-1P40-Tia-1 |
| Alternative Names | Anti-Nucleolysin Tia-1 Isoform P40 antibodyAnti-Rna-Binding Protein Tia-1 antibodyAnti-T-Cell-Restricted Intracellular Antigen-1 antibodyAnti-Tia-1 antibodyAnti-P40-Tia-1 antibodyAnti-TIA1 antibody |
| Positive Control | Tonsil. |
Information sourced from Uniprot.org
