• Formalin-fixed, paraffin-embedded human nasal T/NK cell lymphoma stained with anti-TIA-1 antibody using peroxidase-conjugate and DAB chromogen. Note the cytoplasmic granular staining of lymphoma cells
  • Formalin-fixed, paraffin-embedded human nasal T/NK cell lymphoma stained with anti-TIA-1 antibody using peroxidase-conjugate and DAB chromogen. Note the cytoplasmic granular staining of lymphoma cells
  • Formalin-fixed, paraffin-embedded human nasal T/NK cell lymphoma stained with anti-TIA-1 antibody using peroxidase-conjugate and DAB chromogen. Note the cytoplasmic granular staining of lymphoma cells
  • Formalin-fixed, paraffin-embedded human nasal T/NK cell lymphoma stained with anti-TIA-1 antibody using peroxidase-conjugate and DAB chromogen. Note the cytoplasmic granular staining of lymphoma cells

Anti-TIA1 antibody (STJ180256)

SKU:
STJ180256
Current Stock:
Host: Mouse
Applications: IHC-p
Reactivity: Human
Short Description: Mouse monoclonal primary antibody against TIA1.
Note: FOR RESEARCH USE ONLY (RUO).
Clonality: Monoclonal
Clone ID: 2G9A10F5
Conjugation: Unconjugated
Formulation: Purified antibody diluted in Tris‐HCI buffer containing stabilizing protein and <0.1% sodium azide.
Storage Instruction: Store at 2‐8°C for up to 24 months. Predilute: Ready to use, no reconstitution necessary. Concentrate: Use dilution range and appropriate lab‐standardized diluent. Stability after dilution: 7 days at 24°C, 3 months at 2‐8°C, 6months at ‐20°C.
Isotype: IgG1 Kappa
Dilution Range: 1:100
Uniprot ID: TIA1_HUMAN
Gene ID: 7072
Gene Symbol: TIA1
Immunogen: Human bone marrow malignant cells from a non‐B, non‐T acute leukemia
Background The T cell intracellular antigen 1 (TIA‐1) is a 17‐kDa cytoplasmic granule associated protein also designated as GMP‐17, for granule membrane protein of 17 kDa. The GMP‐ 17/TIA‐1 molecule is expressed in cells possessing cytolytic potential and could be involved in the signaling cascade of Fas (CD95) ‐mediated apoptosis. Within hematopoietic cell lines, the 2G9 monoclonal antibody (mAb) reacts with about 90% of CD16+, 50 – 60% of CD8+, and less than 10% of CD4+ normal peripheral blood lymphocytes. It reacts with almost all monocytes and granulocytes. This antibody also reacts with CD4+ activated T‐cell clones, activated NK cell clones, and Con activated thymocytes, but not with B lymphocytes or B‐cell lines.
Database Links Reactome: R-HSA-6803529
Cellular Localisation Cytoplasm
Stress Granule
Nucleus
Accumulates In Cytoplasmic Stress Granules (Sg) Following Cellular Damage
Protein Name Nucleolysin Tia-1 Isoform P40
Rna-Binding Protein Tia-1
T-Cell-Restricted Intracellular Antigen-1
Tia-1
P40-Tia-1
Alternative Names Anti-Nucleolysin Tia-1 Isoform P40 antibody
Anti-Rna-Binding Protein Tia-1 antibody
Anti-T-Cell-Restricted Intracellular Antigen-1 antibody
Anti-Tia-1 antibody
Anti-P40-Tia-1 antibody
Anti-TIA1 antibody
Positive Control Tonsil.

Information sourced from Uniprot.org

6 months standard