| Host: | Goat |
| Applications: | Pep-ELISA/WB |
| Reactivity: | Human/Mouse/Rat/Dog/Pig |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-TGIF2 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:16000.WB: Approx 22kDa band observed in lysates of A431, A549 and HEK293 cell lines (calculated MW of 25.9kDa according to NP_068581.1). Recommended concentration: 0.3-1.0µg/ml. |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | TGIF2 |
| Gene ID: | 60436 |
| Uniprot ID: | TGIF2_HUMAN |
| Immunogen Region: | Internal |
| Accession Number: | NP_068581.1 |
| Immunogen Sequence: | EMELQKQQDP |
| Post Translational Modifications | The C-terminal part is phosphorylated in response to EGF signaling by the Ras/MAPK pathway. |
| Function | Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins. |
| Protein Name | Homeobox Protein Tgif25'-Tg-3'-Interacting Factor 2Tgf-Beta-Induced Transcription Factor 2Tgfb-Induced Factor 2 |
| Database Links | Reactome: R-HSA-2173795Reactome: R-HSA-2173796 |
| Cellular Localisation | NucleusExcluded From Nucleoli |
| Alternative Antibody Names | Anti-Homeobox Protein Tgif2 antibodyAnti-5'-Tg-3'-Interacting Factor 2 antibodyAnti-Tgf-Beta-Induced Transcription Factor 2 antibodyAnti-Tgfb-Induced Factor 2 antibodyAnti-TGIF2 antibody |
Information sourced from Uniprot.org