| Post Translational Modifications | Following B-cell or T-cell receptors engagement, translocates to the plasma membrane where it gets phosphorylated at Tyr-519. Undergoes also tyrosine phosphorylation during platelet activation. |
| Function | Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. Required for TCR-dependent IL2 gene induction. Phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signaling. Mediates signals that negatively regulate IL2RA expression induced by TCR cross-linking. Plays a redundant role to BTK in BCR-signaling for B-cell development and activation, especially by phosphorylating STAP1, a BCR-signaling protein. Required in mast cells for efficient cytokine production. Involved in both growth and differentiation mechanisms of myeloid cells through activation by the granulocyte colony-stimulating factor CSF3, a critical cytokine to promoting the growth, differentiation, and functional activation of myeloid cells. Participates in platelet signaling downstream of integrin activation. Cooperates with JAK2 through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. GRB10, a negative modifier of the FOS activation pathway, is another substrate of TEC. TEC is involved in G protein-coupled receptor- and integrin-mediated signalings in blood platelets. Plays a role in hepatocyte proliferation and liver regeneration and is involved in HGF-induced ERK signaling pathway. TEC regulates also FGF2 unconventional secretion (endoplasmic reticulum (ER)/Golgi-independent mechanism) under various physiological conditions through phosphorylation of FGF2 'Tyr-215'. May also be involved in the regulation of osteoclast differentiation. |
| Protein Name | Tyrosine-Protein Kinase Tec |
| Database Links | Reactome: R-HSA-1433557Reactome: R-HSA-2871809Reactome: R-HSA-512988 |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane ProteinCytoskeletonFollowing B-Cell Or T-Cell Receptors Activation By AntigenTranslocates To The Plasma Membrane Through Its Ph DomainThrombin And Integrin Engagement Induces Translocation Of Tec To The Cytoskeleton During Platelet ActivationIn Cardiac MyocytesAssumes A Diffuse Intracellular Localization Under Basal Conditions But Is Recruited To Striated Structures Upon Various StimuliIncluding Atp |
| Alternative Antibody Names | Anti-Tyrosine-Protein Kinase Tec antibodyAnti-TEC antibodyAnti-PSCTK4 antibody |
Information sourced from Uniprot.org
